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Article

Activation-induced cytidine deaminase: structure-function relationship as based on the study of mutants.

Human mutation - 1 Dec 2006

Durandy Anne, Peron Sophie, Taubenheim Nadine, Fischer Alain

Abstract excerpt

Activation-induced cytidine deaminase (AID; gene symbol AICDA) is the key molecule required to induce immunoglobulin (Ig) class switch recombination (CSR) and somatic hypermutation (SHM) of the variable regions of Ig genes. Its deficiency causes a form of hyper-IgM (HIGM) syndrome. The study of natural AID mutants associated with HIGM as well as engineered mutants led to the characterization of the active domains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16964591
DOI: 10.1002/humu.20414

Genes

AICDA

Provenance

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