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Article

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas

29 Feb 2016

Abstract excerpt

Loss of the tumor suppressor gene PTEN is implicated in breast cancer progression and resistance to targeted therapies, and is thought to promote tumorigenesis by activating PI3K signaling. In a transgenic model of breast cancer, Pten suppression using a tetracycline-regulatable short hairpin (sh)RNA cooperates with human epidermal growth factor receptor 2 (HER2/neu), leading to aggressive and metastatic disease...

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Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 26929372
DOI: 10.1073/pnas.1523693113

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