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Article

PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.

The American journal of pathology - 1 Oct 2010

Esteva Francisco J, Guo Hua, Zhang Siyuan, Santa-Maria Cesar, Stone Steven, Lanchbury Jerry S, Sahin Aysegul A, Hortobagyi Gabriel N, Yu Dihua

Abstract excerpt

Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab sensitivity in HER2-overexpressing breast cancer. Because PTEN opposes the downstream signaling of phosphoinositide 3-kinase (PI3K), we investigated the role of PTEN and other components of the PI3K pathway in trastuzumab resistance. We analyzed the status of PTEN, p-AKT-Ser473, and p-p70S6K-Thr389 using immunohistochemistry. PIK3CA mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Ductal, Breast

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Share to Immunoenzyme Techniques

Share to Receptors, Progesterone

Share to Ribosomal Protein S6 Kinases, 70-kDa

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Source

Open in PubMed Open full text

Identifiers

PMID: 20813970
DOI: 10.2353/ajpath.2010.090885
PMCID: PMC2947262

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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