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Comparing isogenic strains of Beijing genotype Mycobacterium tuberculosis after acquisition of Isoniazid resistance: A proteomics approach.

Proteomics - 1 May 2016

Nieto R Luisa María, Mehaffy Carolina, Dobos Karen M

Abstract excerpt

We determined differences in the protein abundance among two isogenic strains of Mycobacterium tuberculosis (Mtb) with different Isoniazid (INH) susceptibility profiles. The strains were isolated from a pulmonary tuberculosis patient before and after drug treatment. LC-MS/MS analysis identified 46 Mtb proteins with altered abundance after INH resistance acquisition. Protein abundance comparisons were done...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26929115
DOI: 10.1002/pmic.201500403
PMCID: PMC5074239

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