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Biochemical Characterization of Isoniazid-resistant Mycobacterium tuberculosis: Can the Analysis of Clonal Strains Reveal Novel Targetable Pathways?

Molecular & cellular proteomics : MCP - 1 Sept 2018

Nieto R Luisa Maria, Mehaffy Carolina, Islam M Nurul, Fitzgerald Bryna, Belisle John, Prenni Jessica, Dobos Karen

Abstract excerpt

Tuberculosis (TB) continues to be an important public health threat worldwide, due in part to drug resistant Mycobacterium tuberculosis (Mtb) strains. The United States recently reported a shortage of isoniazid (INH), which could drive higher INH resistance rates. Changes in the Mtb proteome before and after acquisition of INH resistance in a clean genetic background remain understudied and may elucidate...

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PMID: 29844232
DOI: 10.1074/mcp.RA118.000821
PMCID: PMC6126390

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