Article
Disclosure of selective advantages in the "modern" sublineage of the Mycobacterium tuberculosis Beijing genotype family by quantitative proteomics.
Molecular & cellular proteomics : MCP - 1 Oct 2014
de Keijzer Jeroen, de Haas Petra E, de Ru Arnoud H, van Veelen Peter A, van Soolingen Dick
Abstract excerpt
The Mycobacterium tuberculosis Beijing genotype, consisting of the more ancient (atypical) and modern (typical) emerging sublineage, is one of the most prevalent and genetically conserved genotype families and has often been associated with multidrug resistance. In this study, we employed a 2D-LC-FTICR MS approach, combined with dimethylation of tryptic peptides, to systematically compare protein abundance levels...
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