Article
Mechanisms of Phenotypic Rifampicin Tolerance in Mycobacterium tuberculosis Beijing Genotype Strain B0/W148 Revealed by Proteomics.
Journal of proteome research - 1 Apr 2016
de Keijzer Jeroen, Mulder Arnout, de Beer Jessica, de Ru Arnoud H, van Veelen Peter A, van Soolingen Dick
Abstract excerpt
The "successful" Russian clone B0/W148 of Mycobacterium tuberculosis Beijing is well-known for its capacity to develop antibiotic resistance. During treatment, resistant mutants can occur that have inheritable resistance to specific antibiotics. Next to mutations, M. tuberculosis has several mechanisms that increase their tolerance to a variety of antibiotics. Insights in the phenotypic mechanisms that contribute...
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