Article
Quantitative Proteomics Reveals Novel Insights into Isoniazid Susceptibility in Mycobacteria Mediated by a Universal Stress Protein
9 Feb 2015
Abstract excerpt
Tuberculosis (TB) is caused by the ancient pathogen, Mycobacterium tuberculosis, and is one of the most serious infectious diseases in the world. Isoniazid (INH) is an important first-line drug for the treatment of active and latent TB. INH resistance is an increasing problem in the treatment of TB. Phenotypic resistance to INH, however, is poorly understood. In this study, we constructed a strain of...
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