Close Related Drug-Resistance Beijing Isolates of Mycobacterium tuberculosis Reveal a Different Transcriptomic Signature in a Murine Disease Progression Model.

doi:10.3390/ijms23095157

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Close Related Drug-Resistance Beijing Isolates of Mycobacterium tuberculosis Reveal a Different Transcriptomic Signature in a Murine Disease Progression Model.

International journal of molecular sciences - 5 May 2022

Cerezo-Cortés María Irene, Rodríguez-Castillo Juan Germán, Mata-Espinosa Dulce Adriana, Bini Estela Isabel, Barrios-Payan Jorge, Zatarain-Barrón Zyanya Lucia, Anzola Juan Manuel, Cornejo-Granados Fernanda, Ochoa-Leyva Adrian, Del Portillo Patricia, Murcia Martha Isabel, Hernández-Pando Rogelio

Abstract excerpt

Mycobacterium tuberculosis (MTB) lineage 2/Beijing is associated with high virulence and drug resistance worldwide. In Colombia, the Beijing genotype has circulated since 1997, predominantly on the pacific coast, with the Beijing-Like SIT-190 being more prevalent. This genotype conforms to a drug-resistant cluster and shows a fatal outcome in patients. To better understand virulence determinants, we performed a...

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PMID: 35563545
DOI: 10.3390/ijms23095157
PMCID: PMC9100210

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