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Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strains.

The Lancet. Infectious diseases - 1 Feb 2010

Parwati Ida, van Crevel Reinout, van Soolingen Dick

Abstract excerpt

The wide geographic distribution of one clade of Mycobacterium tuberculosis, the Beijing genotype family, and its genetic homogeneity, suggests that strains belonging to this grouping might have a selective advantage over other M tuberculosis strains. This hypothesis was addressed by reviewing molecular-epidemiological, experimental, and clinical studies. Beijing strains represent about 50% of strains in east...

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PMID: 20113979
DOI: 10.1016/S1473-3099(09)70330-5

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