Article
Methylenetetrahydrofolate reductase polymorphisms and methotrexate: no association with response to therapy nor with drug-related adverse events in an Italian population of rheumatic patients.
Clinical and experimental rheumatology - 1 Jan 2000
Taraborelli M, Andreoli L, Archetti S, Ferrari M, Cattaneo R, Tincani A
Abstract excerpt
OBJECTIVE: MTHFR is an enzyme involved in the folate pathway. It has been suggested that common polymorphisms in its gene (C677T and A1298C) could be related to different methotrexate (MTX) response and toxicity in rheumatoid arthritis (RA) patients. Agreement has not been found yet and there is...
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