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Article

Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.

Nature medicine - 1 Apr 2016

Song SungWon, Miranda Carlos J, Braun Lyndsey, Meyer Kathrin, Frakes Ashley E, Ferraiuolo Laura, Likhite Shibi, Bevan Adam K, Foust Kevin D, McConnell Michael J, Walker Christopher M, Kaspar Brian K

Abstract excerpt

Astrocytes isolated from individuals with amyotrophic lateral sclerosis (ALS) are toxic to motor neurons (MNs) and play a non-cell autonomous role in disease pathogenesis. The mechanisms underlying the susceptibility of MNs to cell death remain unclear. Here we report that astrocytes derived from either mice bearing mutations in genes associated with ALS or human subjects with ALS reduce the expression of major...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26928464
DOI: 10.1038/nm.4052
PMCID: PMC4823173

Genes

KIR3DL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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