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Article

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.

Nature neuroscience - 1 Mar 2008

Yamanaka Koji, Chun Seung Joo, Boillee Severine, Fujimori-Tonou Noriko, Yamashita Hirofumi, Gutmann David H, Takahashi Ryosuke, Misawa Hidemi, Cleveland Don W

Abstract excerpt

Dominant mutations in superoxide dismutase cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease that is characterized by the loss of motor neurons. Using mice carrying a deletable mutant gene, diminished mutant expression in astrocytes did not affect onset, but delayed microglial activation and sharply slowed later disease progression. These findings demonstrate that mutant...

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Identifiers

PMID: 18246065
DOI: 10.1038/nn2047
PMCID: PMC3137510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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