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Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression

19 Oct 2016

Abstract excerpt

The role of nuclear receptor PXR in detoxification and clearance of xenobiotics and endobiotics is well-established. However, its projected role in hepatic cancer is rather illusive where its expression is reported altered in different cancers depending on the tissue-type and microenvironment. The expression of PXR, its target genes and their biological or clinical significance have not been examined in hepatic...

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PMID: 27760163
DOI: 10.1371/journal.pone.0164087

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