Macrophage polarization: convergence point targeted by Mycobacterium tuberculosis and HIV

Abstract excerpt

In the arms race of host-microbe co-evolution, macrophages (Mɸs) have been endowed with strategies to neutralize pathogenic challenge while preserving host integrity. During steady-states conditions, Mɸs perform multiple house-keeping functions governed by their differentiation state, tissue distribution, and signals from the microenvironment. In response to pathogenic challenge and host mediators, however, Mɸs...

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