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Genome-wide integrative analysis identified SNP-miRNA-mRNA interaction networks in peripheral blood mononuclear cells.

Epigenomics - 1 Oct 2017

Lin Xiang, Xia Wei, Ji Wei, Xie Fang-Fei, He Pei, Zhu Xiao-Wei, Zhang Yong-Hong, Deng Fei-Yan, Lei Shu-Feng

Abstract excerpt

AIM: To detect SNP-miRNA-mRNA interaction networks and to elucidate miRNA-mediated regulation effects on mRNA expression. MATERIALS & METHODS: In human peripheral blood mononuclear cells of 43 females, SNP-miRNA-mRNA interaction networks were established through an integrative analysis. Then causal inference test was followed to detect miRNA-mediated effects on mRNA expressions. RESULTS: About 167 trios...

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PMID: 28877608
DOI: 10.2217/epi-2017-0042

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