Article
MicroRNAs enrichment in GWAS of complex human phenotypes.
BMC genomics - 16 Apr 2015
Goulart Luiz F, Bettella Francesco, Sønderby Ida E, Schork Andrew J, Thompson Wesley K, Mattingsdal Morten, Steen Vidar M, Zuber Verena, Wang Yunpeng, Dale Anders M, Andreassen Ole A, Djurovic Srdjan
Abstract excerpt
BACKGROUND: The genotype information carried by Genome-wide association studies (GWAS) seems to have the potential to explain more of the 'missing heritability' of complex human phenotypes, given improved statistical approaches. Several lines of evidence support the involvement of microRNA (miRNA) and other non-coding RNA in complex human traits and diseases. We employed a novel, genetic annotation-informed...
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