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Article

Role of miRNAs in the pathogenesis of psoriasis and psoriatic arthritis: a genome-wide Mendelian randomization study.

Clinical rheumatology - 1 Apr 2025

Li Chanxiu, Sun Zhanxue

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) are critical in the onset and treatment of skin diseases, but the miRNAs causally associated with psoriasis (PSO) and psoriatic arthritis (PsA) remain unclear. This study aims to identify miRNAs with causal associations with PSO and PsA. METHODS: Five Mendelian randomization (MR) methods were employed, using miRNA expression quantitative trait loci (mirQTL) data as exposure...

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PMID: 39985656
DOI: 10.1007/s10067-025-07374-3

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