Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism in the ZNF804A Gene and Variation in D1 and D2/D3 Dopamine Receptor Availability in the Healthy Human Brain: A Dual Positron Emission Tomography Study.

Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 Jan 2023

Hegarty Catherine E, Ianni Angela M, Kohn Philip D, Kolachana Bhaskar, Gregory Michael, Masdeu Joseph C, Eisenberg Daniel P, Berman Karen F

Abstract excerpt

BACKGROUND: The rs1344706 single nucleotide polymorphism in the ZNF804A gene has been associated with risk for psychosis in multiple genome-wide association studies, yet mechanisms underlying this association are not known. Given preclinical work suggesting an impact of ZNF804A on dopamine receptor gene transcription and clinical studies establishing dopaminergic dysfunction in patients with schizophrenia, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine

Share to Genome-Wide Association Study

Share to Genotype

Share to Kruppel-Like Transcription Factors

Share to Positron-Emission Tomography

Share to Receptors, Dopamine

Source

Open in PubMed Open full text

Identifiers

PMID: 33712377
DOI: 10.1016/j.bpsc.2020.12.006
PMCID: PMC10501410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism in the ZNF804A Gene and Variation in D1 and D2/D3 Dopamine Receptor Availability in the Healthy Human Brain: A Dual Positron Emission Tomography Study.PMID 33712377Read ↗

The impact of common dopamine D2 receptor gene polymorphisms on D2/3 receptor availability: C957T as a key determinant in putamen and ventral striatum.Semantic proximity Read ↗

The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes.Semantic proximity Read ↗

ZNF804A variants confer risk for heroin addiction and affect decision making and gray matter volume in heroin abusers.Semantic proximity Read ↗

The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions.Semantic proximity Read ↗

A schizophrenia risk gene, ZNF804A, influences neuroanatomical and neurocognitive phenotypes.Semantic proximity Read ↗

Association between variants of zinc finger genes and psychiatric disorders: systematic review and meta-analysis.Semantic proximity Read ↗

The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function.Semantic proximity Read ↗

Neural mechanisms of a genome-wide supported psychosis variant.Semantic proximity Read ↗

Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.Semantic proximity Read ↗

ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.Semantic proximity Read ↗

ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults.Semantic proximity Read ↗

Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.