Article
Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG.
RNA (New York, N.Y.) - 1 Sept 2009
Gregory Steven T, Demirci Hasan, Belardinelli Riccardo, Monshupanee Tanakarn, Gualerzi Claudio, Dahlberg Albert E, Jogl Gerwald
Abstract excerpt
The RsmG methyltransferase is responsible for N(7) methylation of G527 of 16S rRNA in bacteria. Here, we report the identification of the Thermus thermophilus rsmG gene, the isolation of rsmG mutants, and the solution of RsmG X-ray crystal structures at up to 1.5 A resolution. Like their counterparts in other species, T. thermophilus rsmG mutants are weakly resistant to the aminoglycoside antibiotic streptomycin....
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