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Article

In vitro reconstitution and activity of a C/D box methylation guide ribonucleoprotein complex.

Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002

Omer Arina D, Ziesche Sonia, Ebhardt Holger, Dennis Patrick P

Abstract excerpt

The genomes of hyperthermophilic Archaea encode dozens of methylation guide, C/D box small RNAs that guide 2'-O-methylation of ribose to specific sites in rRNA and various tRNAs. The genes encoding the Sulfolobus homologues of eukaryotic proteins that are known to be present in C/D box small nucleolar ribonucleoprotein (snoRNP) complexes were cloned, and the proteins (aFIB, aNOP56, and aL7a) were expressed and...

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Identifiers

PMID: 11959980
DOI: 10.1073/pnas.082101999
PMCID: PMC122762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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