Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIF-2α mediates a marked increase in migration and stemness characteristics in a subset of glioma cells under hypoxia by activating an Oct-4/Sox-2-Mena (INV) axis

27 Feb 2016

Abstract excerpt

Hypoxia is a salient feature of most solid tumors and plays a central role in tumor progression owing to its multiple contributions to therapeutic resistance, metastasis, angiogenesis and stemness properties. Reports exist in literature about hypoxia increasing stemness characteristics and invasiveness potential of malignant cells. In order to delineate molecular crosstalk among factors driving glioma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26923292
DOI: 10.1016/j.biocel.2016.02.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIF-2α mediates a marked increase in migration and stemness characteristics in a subset of glioma cells under hypoxia by activating an Oct-4/Sox-2-Mena (INV) axisPMID 26923292Read ↗

Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell linesSemantic proximity Read ↗

The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma.Semantic proximity Read ↗

Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive nicheSemantic proximity Read ↗

Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profileSemantic proximity Read ↗

SOX transcription factors and glioma stem cells: Choosing between stemness and differentiationSemantic proximity Read ↗

Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheresSemantic proximity Read ↗

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2αSemantic proximity Read ↗

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype.Semantic proximity Read ↗

Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastomaSemantic proximity Read ↗

CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells.Semantic proximity Read ↗

HRI Inhibition by Hemin as a Novel Targeted Therapy for Glioblastoma via the Integrated Stress ResponseSemantic proximity Read ↗

HMGA1 silencing reduces stemness and temozolomide resistance in glioblastoma stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.