Article
Key Role of CD151-integrin Complex in Lung Cancer Metastasis and Mechanisms Involved.
Current medical science - 1 Dec 2020
Peng Dan, Li Peng-Cheng, Liu Tao, Zeng He-Song, Fei Yu-Jie, Liu Zheng-Xiang, Zuo Hou-Juan
Abstract excerpt
Tetraspanin CD151 was found to be upregulated in malignant cell types and has been identified as a tumor metastasis promoter. In this study, we aimed to examine the role of the CD151-integrin complex in lung cancer metastasis and the underlying mechanisms. CD151 QRD194-196 →AAA194-196 mutant was generated and used to transfect A549 human lung adenocarcinoma cells. We found that there was no significant difference...
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