Metastasis‑associated gene MAPK15 promotes the migration and invasion of osteosarcoma cells via the c‑Jun/MMPs pathway

Abstract excerpt

Osteosarcoma (OS) is the most common and destructive primary bone malignancy to affect children and adolescents. Metastases remain the primary cause of death in patients with OS. In the present study, weight gene co‑expressed network analysis (WGCNA) and differentially‑expressed gene analysis were used to identify key genes associated with the metastasis of OS. Reverse transcription‑quantitative PCR and...

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