The Functional Role of PMP22 Gene in the Proliferation and Invasion of Osteosarcoma

Abstract excerpt

BACKGROUND: As the most common primary bone tumor, osteosarcoma has an improved survival rates with advancement of treatment methods. A higher rate of metastasis, however, leads to the aggravation of the disease. Studies have shown that some genes, namely osteosarcoma metastasis-related genes, participate in the process of tumor metastasis. The peripheral myelin protein 22 (PMP22) gene has recently been found to...

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