Article
The catalytically active tyrosine residues of both SPO11-1 and SPO11-2 are required for meiotic double-strand break induction in Arabidopsis.
The Plant cell - 1 Oct 2007
Hartung Frank, Wurz-Wildersinn Rebecca, Fuchs Jörg, Schubert Ingo, Suer Stefanie, Puchta Holger
Abstract excerpt
SPO11, a homolog of the subunit A of the archaebacterial topoisomerase VI, is essential for double-strand break (DSB)-induced initiation of meiotic recombination. In contrast with single homologs in animals and yeasts, three homologs are present in Arabidopsis thaliana and other higher plants. Whereas At SPO11-3 is involved in somatic endoreduplication, At SPO11-1 and, as recently shown, At SPO11-2 are essential...
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