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Article

Pharmacological estrogen administration causes a FSH-independent osteo-anabolic effect requiring ER alpha in osteoblasts.

PloS one - 1 Jan 2012

Seitz Sebastian, Keller Johannes, Schilling Arndt F, Jeschke Anke, Marshall Robert P, Stride Brenda D, Wintermantel Tim, Beil Frank T, Amling Michael, Schütz Günther, Tuckermann Jan, Schinke Thorsten

Abstract excerpt

Postmenopausal osteoporosis is characterized by declining estrogen levels, and estrogen replacement therapy has been proven beneficial for preventing bone loss in affected women. While the physiological functions of estrogen in bone, primarily the inhibition of bone resorption, have been studied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23209701
DOI: 10.1371/journal.pone.0050301
PMCID: PMC3507728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23209701-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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