Article
Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survival of gastric cancer among patients who receiving 5-fluorouracil-based postoperative adjuvant chemotherapy.
Cancer chemotherapy and pharmacology - 1 Apr 2013
Wang Shizhi, Chen Lulu, Zhao Qinghong, Rong Huan, Wang Meilin, Gong Weida, Zhou Jianwei, Wu Dongmei, Zhang Zhengdong
Abstract excerpt
PURPOSE: Several studies have examined the prognostic value of the TP53 Arg72Pro polymorphism (rs1042522) and/or MDM2 SNP309 (rs2279744) in multiple tumors. Our aim was to determine whether these two genetic variants were correlated with clinical outcome of gastric cancer. METHODS: We genotyped the two SNPs, TP53 codon 72 polymorphism and MDM2 SNP309, in 940 gastric cancer patients with complete follow-up...
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