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Article

Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2021

Vecellio Matteo, Chen Liye, Cohen Carla J, Cortes Adrian, Li Yan, Bonham Sarah, Selmi Carlo, Brown Matthew A, Fischer Roman, Knight Julian C, Wordsworth B Paul

Abstract excerpt

OBJECTIVE: To investigate the functional consequences of the single-nucleotide polymorphism rs4648889 in a putative enhancer upstream of the RUNX3 promoter associated with susceptibility to ankylosing spondylitis (AS). METHODS: Using nuclear extracts from Jurkat cells and primary human CD8+ T cells, the effects of rs4648889 on allele-specific transcription factor (TF) binding were investigated by DNA pull-down...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33369221
DOI: 10.1002/art.41628
PMCID: PMC8251554

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