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Article

Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.

Expert reviews in molecular medicine - 8 Apr 2016

Toral-Ojeda Ivan, Aldanondo Garazi, Lasa-Elgarresta Jaione, Lasa-Fernández Haizpea, Fernández-Torrón Roberto, López de Munain Adolfo, Vallejo-Illarramendi Ainara

Abstract excerpt

Limb-girdle muscular dystrophy type 2A (LGMD2A) is a form of muscular dystrophy caused by mutations in calpain 3 (CAPN3). Several studies have implicated Ca2+ dysregulation as an underlying event in several muscular dystrophies, including LGMD2A. In this study we used mouse and human myotube cultures, and muscle biopsies in order to determine whether dysfunction of sarco/endoplasmatic Ca2+-ATPase (SERCA) is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27055500
DOI: 10.1017/erm.2016.9
PMCID: PMC4836212

Genes

CAPN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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