Article
Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion.
PLoS neglected tropical diseases - 1 Nov 2011
Bale Shridhar, Liu Tong, Li Sheng, Wang Yuhao, Abelson Dafna, Fusco Marnie, Woods Virgil L, Saphire Erica Ollmann
Abstract excerpt
BACKGROUND: Ebolavirus belongs to the family filoviridae and causes severe hemorrhagic fever in humans with 50-90% lethality. Detailed understanding of how the viruses attach to and enter new host cells is critical to development of medical interventions. The virus displays a trimeric glycoprotein (GP(1,2)) on its surface that is solely responsible for membrane attachment, virus internalization and fusion....
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