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Article

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population.

Molecular cancer - 20 Feb 2016

Ciccarelli Carmela, Vulcano Francesca, Milazzo Luisa, Gravina Giovanni Luca, Marampon Francesco, Macioce Giampiero, Giampaolo Adele, Tombolini Vincenzo, Di Paolo Virginia, Hassan Hamisa Jane, Zani Bianca Maria

Abstract excerpt

BACKGROUND: The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma. The aim of this study was to investigate the role of the MEK/ERK pathway in controlling the cancer stem-like phenotype using a model of rhabdospheres derived from the embryonal rhabdomyosarcoma cell line (RD). METHODS: Rhabdospheres...

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Source

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Identifiers

PMID: 26897742
DOI: 10.1186/s12943-016-0501-y
PMCID: PMC4761200

Genes

BMX
CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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