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MEK/ERK Inhibitor U0126 Increases the Radiosensitivity of Rhabdomyosarcoma Cells <i>In vitro</i> and <i>In vivo</i> by Downregulating Growth and DNA Repair Signals

1 Jan 2011

Abstract excerpt

Multimodal treatment has improved the outcome of many solid tumors, and in some cases the use of radiosensitizers has significantly contributed to this gain. Activation of the extracellular signaling kinase pathway (MEK/ERK) generally results in stimulation of cell growth and confers a survival advantage playing the major role in human cancer. The potential involvement of this pathway in cellular radiosensitivity...

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PMID: 21220498
DOI: 10.1158/1535-7163.mct-10-0631

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