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Article

Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcoma

20 Jul 2015

Abstract excerpt

Current treatment regimens for rhabdomyosarcoma (RMS), the most common pediatric soft tissue cancer, rely on conventional chemotherapy, and although they show clinical benefit, there is a significant risk of adverse side effects and secondary tumors later in life. Therefore, identifying and targeting sub-populations with higher tumorigenic potential and self-renewing capacity would offer improved patient...

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PMID: 26189795
DOI: 10.1038/onc.2015.267

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