Article
c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines.
Radiation research - 1 Apr 2016
Gravina G L, Festuccia C, Popov V M, Di Rocco A, Colapietro A, Sanità P, Monache S Delle, Musio D, De Felice F, Di Cesare E, Tombolini V, Marampon F
Abstract excerpt
We have previously reported that the MEK/ERK pathway sustains in vitro and in vivo transformed phenotype and radioresistance of embryonal rhabdomyosarcoma (ERMS) cell lines. Furthermore, we found that aberrant MEK/ERK signaling activation promotes c-Myc oncoprotein accumulation. In this study, the role of c-Myc in sustaining the ERMS transformed and radioresistant phenotype is characterized. RD and TE671 cell...
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