Article
Nuclear EGFR-PKM2 axis induces cancer stem cell-like characteristics in irradiation-resistant cells.
Cancer letters - 28 May 2018
Shi Ying, Liu Na, Lai Weiwei, Yan Bin, Chen Ling, Liu Shouping, Liu Shuang, Wang Xiang, Xiao Desheng, Liu Xiaoli, Mao Chao, Jiang Yiqun, Jia Jiantao, Liu Yating, Yang Rui, Cao Ya, Tao Yongguang
Abstract excerpt
Radiation therapy has become an important tool in the treatment of cancer patients, but most patients relapse within 5 years. Relapse is due to the presence of cancer stem cells (CSCs), but the molecular mechanism of radioresistance in CSCs remains largely elusive. Here, we found that irradiation-resistant (IR) cells exhibited increased stem cell-like properties together with elevated anchorage-independent growth...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.