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Article

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.

Brain : a journal of neurology - 1 Sept 2011

Neumann Manuela, Bentmann Eva, Dormann Dorothee, Jawaid Ali, DeJesus-Hernandez Mariely, Ansorge Olaf, Roeber Sigrun, Kretzschmar Hans A, Munoz David G, Kusaka Hirofumi, Yokota Osamu, Ang Lee-Cyn, Bilbao Juan, Rademakers Rosa, Haass Christian, Mackenzie Ian R A

Abstract excerpt

Accumulation of the DNA/RNA binding protein fused in sarcoma as cytoplasmic inclusions in neurons and glial cells is the pathological hallmark of all patients with amyotrophic lateral sclerosis with mutations in FUS as well as in several subtypes of frontotemporal lobar degeneration, which are not associated with FUS mutations. The mechanisms leading to inclusion formation and fused in sarcoma-associated...

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Source

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Identifiers

PMID: 21856723
DOI: 10.1093/brain/awr201
PMCID: PMC3170539

Genes

FUS
TAF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.PMID 21856723Read ↗

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.Semantic proximity Read ↗

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Autosomal dominant inheritance of rapidly progressive amyotrophic lateral sclerosis due to a truncation mutation in the fused in sarcoma (FUS) gene.Semantic proximity Read ↗

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Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUSSemantic proximity Read ↗

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Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.Semantic proximity Read ↗

Gene Expression Responses to FUS, EWS, and TAF15 Reduction and Stress Granule Sequestration Analyses Identifies FET-Protein Non-Redundant FunctionsSemantic proximity Read ↗

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