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Article

ALS mutations in TLS/FUS disrupt target gene expression.

Genes & development - 15 Aug 2015

Coady Tristan H, Manley James L

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is caused by mutations in a number of genes, including the gene encoding the RNA/DNA-binding protein translocated in liposarcoma or fused in sarcoma (TLS/FUS or FUS). Previously, we identified a number of FUS target genes, among them MECP2. To investigate how ALS mutations in FUS might impact target gene expression, we examined the effects of several FUS derivatives harboring...

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Share to Amyotrophic Lateral Sclerosis
Share to Cell Line, Tumor
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyl-CpG-Binding Protein 2

Share to Protein Transport

Share to RNA-Binding Protein FUS

Share to RNA Splicing

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Source

Open in PubMed Open full text

Identifiers

PMID: 26251528
DOI: 10.1101/gad.267286.115
PMCID: PMC4561479

Genes

FUS
MECP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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