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Article

DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis

19 Feb 2016

Abstract excerpt

DDX3, a subunit of CK1ε, phosphorylates Dvl2 to promote β-catenin activation. Overexpression of the Dvl2 protein results in potent activation of β-catenin/TCF signaling in colorectal cancer. Therefore, we hypothesized that DDX3 might promote tumor invasion via the CK1ε/Dvl2 axis due to β-catenin/TCF activation. Western blotting showed that β-catenin expression was decreased by DDX3 knockdown and increased by DDX3...

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Share to Cancer-related gene regulation
Share to Genetic factors in colorectal cancer
Share to Wnt/β-catenin signaling in development and cancer

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PMID: 26892600
DOI: 10.1038/srep21483

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