Back to search

Article

FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin Destruction Complex and Enhance Wnt Signaling Pathway Activation

2024-10-30

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Elevated FNDC1 expression in gastric cancer (GC) cells activates the Wnt/β-catenin pathway, contributing to their malignant traits. However, the exact mechanism governing this process remains unclear. <bold>Methods</bold>: Bioinformatics analyses were used to identify the expression of FDNC1 in pan-cancer, its correlation with clinical outcomes, and biological f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d2711119-f052-58ea-b8cd-4109cb3a17e9
DOI
10.21203/rs.3.rs-5333568/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin Destruction Complex and Enhance Wnt Signaling Pathway ActivationDOI 10.21203/rs.3.rs-5333568/v1
FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin Destruction Complex in Gastric CancerSemantic proximity
Cyclin G2 suppresses Wnt/β-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1Semantic proximity
DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing HIF‐1α Ubiquitination and DegradationSemantic proximity
DEPDC1 Promotes Thyroid Cancer Migration, Invasion, and Proliferation, and Correlates with Poor PrognosisSemantic proximity
Expression and Prognostic Impact of FZDs in Pancreatic AdenocarcinomaSemantic proximity
Overexpression of FNDC1 Relates to Poor Prognosis and Its Knockdown Impairs Cell Invasion and Migration in Gastric CancerSemantic proximity
USP51/ZEB1/ACTA2 axis promotes mesenchymal phenotype in gastric cancer and is associated with low cohesion characteristicsSemantic proximity
The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathwaySemantic proximity
FNDC3B, Targeted by miR-125a-5p and miR-217, Promotes the Proliferation and Invasion of Colorectal Cancer Cells via PI3K/mTOR SignalingSemantic proximity
The TCGA and GEO databases identify COL5A2 as a poorly prognostic gene in patients with advanced gastric cancerSemantic proximity
Role for Daple in non‐canonical Wnt signaling during gastric cancer invasion and metastasisSemantic proximity
Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 Genes Enhance Gastric Cancer Development in the Presence of Helicobacter PyloriSemantic proximity
Select a neighboring publication to make it the new centre.