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Article

Modeling Chemotherapy Resistant Leukemia In Vitro.

Journal of visualized experiments : JoVE - 9 Feb 2016

Slone William L, Moses Blake S, Evans Rebecca, Piktel Debbie, Martin Karen H, Petros William, Craig Michael, Gibson Laura F

Abstract excerpt

It is well established that the bone marrow microenvironment provides a unique site of sanctuary for hematopoietic diseases that both initiate and progress in this site. The model presented in the current report utilizes human primary bone marrow stromal cells and osteoblasts as two representative cell types from the marrow niche that influence tumor cell phenotype. The in vitro co-culture conditions described...

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Identifiers

PMID: 26891147
DOI: 10.3791/53645
PMCID: PMC4781739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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