Article
Prediction and Validation of Disease Genes Using HeteSim Scores.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Zeng Xiangxiang, Liao Yuanlu, Liu Yuansheng, Zou Quan
Abstract excerpt
Deciphering the gene disease association is an important goal in biomedical research. In this paper, we use a novel relevance measure, called HeteSim, to prioritize candidate disease genes. Two methods based on heterogeneous networks constructed using protein-protein interaction, gene-phenotype associations, and phenotype-phenotype similarity, are presented. In HeteSim_MultiPath (HSMP), HeteSim scores of...
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