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Beyond effector caspase inhibition

1 Jan 2011

Abstract excerpt

Malignant gliomas are the most common and lethal primary central nervous system cancer. Glioblastoma mutliforme (GBM), the most aggressive of these neoplasms, are generally lethal within 2 years of diagnosis due in part to the intense apoptosis resistance of its cancer cells, hence poor therapeutic response to conventional and targeted therapies. Twenty years of research has uncovered key genetic events involved...

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PMID: 21200141
DOI: 10.4161/cc.10.1.14365

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