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Article

Evaluating the Role of Cellular Immune Responses in the Emergence of HCV NS3 Resistance Mutations During Protease Inhibitor Therapy.

Viral immunology - 1 May 2016

Abdel-Hameed Enass A, Rouster Susan D, Ji Hong, Ulm Ashley, Hetta Helal F, Anwar Nadeem, Sherman Kenneth E, Shata Mohamed Tarek M

Abstract excerpt

The efficacy of protease inhibitor drugs in hepatitis C virus (HCV) treatment is limited by the selection and expansion of drug-resistant mutations. HCV replication is error-prone and genetic variability within the dominant epitopes ensures its persistence. The aims of this study are to evaluate the role of cellular immune response in the emergence of HCV protease resistance mutations and its effects on treatment...

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Identifiers

PMID: 26885675
DOI: 10.1089/vim.2015.0093
PMCID: PMC4860622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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