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Article

Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy.

PloS one - 1 Jan 2016

Dietz Julia, Rupp Daniel, Susser Simone, Vermehren Johannes, Peiffer Kai-Henrik, Filmann Natalie, Bon Dimitra, Kuntzen Thomas, Mauss Stefan, Grammatikos Georgios, Perner Dany, Berkowski Caterina, Herrmann Eva, Zeuzem Stefan, Bartenschlager Ralf, Sarrazin Christoph

Abstract excerpt

Triple therapy of chronic hepatitis C virus (HCV) infection with boceprevir (BOC) or telaprevir (TVR) leads to virologic failure in many patients which is often associated with the selection of resistance-associated variants (RAVs). These resistance profiles are of importance for the selection of potential rescue treatment options. In this study, we sequenced baseline NS3 RAVs population-based and investigated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27281344
DOI: 10.1371/journal.pone.0156731
PMCID: PMC4900565

Genes

BOC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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