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Article

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue.

Molecules and cells - 1 Mar 2016

Han Songhee, Pham Tan-Viet, Kim Joo-Hwan, Lim Young-Ran, Park Hyoung-Goo, Cha Gun-Su, Yun Chul-Ho, Chun Young-Jin, Kang Lin-Woo, Kim Donghak

Abstract excerpt

CYP107W1 from Streptomyces avermitilis is a cytochrome P450 enzyme involved in the biosynthesis of macrolide oligomycin A. A previous study reported that CYP107W1 regioselectively hydroxylated C12 of oligomycin C to produce oligomycin A, and the crystal structure of ligand free CYP107W1 was determined. Here, we analyzed the structural properties of the CYP107W1-oligomycin A complex and characterized the...

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Identifiers

PMID: 26883908
DOI: 10.14348/molcells.2016.2226
PMCID: PMC4794603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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