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Article

Allosteric communication of tryptophan synthase. Functional and regulatory properties of the beta S178P mutant.

The Journal of biological chemistry - 25 May 2001

Marabotti A, De Biase D, Tramonti A, Bettati S, Mozzarelli A

Abstract excerpt

The alpha(2)beta(2) tryptophan synthase complex is a model enzyme for understanding allosteric regulation. We report the functional and regulatory properties of the betaS178P mutant. Ser-178 is located at the end of helix 6 of the beta subunit, belonging to the domain involved in intersubunit signaling. The carbonyl group of betaSer-178 is hydrogen bonded to Gly-181 of loop 6 of the alpha subunit only when alpha...

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Identifiers

PMID: 11278986
DOI: 10.1074/jbc.M011781200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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