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Article

Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase.

Chemistry & biology - 1 Sept 1995

Kealey J T, Eckstein J, Santi D V

Abstract excerpt

BACKGROUND: Thymidylate synthase (TS; EC 2.1.1.45) catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) by 5,10-methylene-5,6,7,8-tetrahydrofolate (CH2H4folate) to produce 2'-deoxythymidine-5'-monophosphate (dTMP) and 7,8-dihydrofolate (H2folate). Major advances in the understanding of the mechanism of TS have been made by studying site-specific mutants of the enzyme. Trp82 is completely...

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Identifiers

PMID: 9383465
DOI: 10.1016/1074-5521(95)90125-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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