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It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease.

Oxidative medicine and cellular longevity - 1 Jan 2016

Tramutola Antonella, Di Domenico Fabio, Barone Eugenio, Perluigi Marzia, Butterfield D Allan

Abstract excerpt

Free radical-mediated damage to macromolecules and the resulting oxidative modification of different cellular components are a common feature of aging, and this process becomes much more pronounced in age-associated pathologies, including Alzheimer disease (AD). In particular, proteins are particularly sensitive to oxidative stress-induced damage and these irreversible modifications lead to the alteration of...

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Identifiers

PMID: 26881020
DOI: 10.1155/2016/2756068
PMCID: PMC4736377

Genes

UCHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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