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Article

Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.

Oncogene - 1 Aug 2018

Lee Junguee, Yi Shinae, Won Minho, Song Young Shin, Yi Hyon-Seung, Park Young Joo, Park Ki Cheol, Kim Jung Tae, Chang Joon Young, Lee Min Joung, Sul Hae Joung, Choi Ji Eun, Kim Koon Soon, Kero Jukka, Kim Joon, Shong Minho

Abstract excerpt

Primary cilia are microtubule-based, dynamic organelles characterized by continuous assembly and disassembly. The intraflagellar transport (IFT) machinery, including IFT88 in cilia, is involved in the maintenance of bidirectional motility along the axonemes, which is required for ciliogenesis and functional competence. Cancer cells are frequently associated with loss of primary cilia and IFT functions. However,...

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Identifiers

PMID: 29743590
DOI: 10.1038/s41388-018-0211-6

Genes

IFT88

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